– Retrospective Health Economic Data Show Addition of OFIRMEV to Treat Post-Operative Pain Versus IV Opioids Alone Associated With Shorter Length of Stay, Decreased Hospital Costs –
CHESTERFIELD, United Kingdom – Aug. 31, 2016 – Mallinckrodt Pharmaceuticals (NYSE: MNK), a leading global specialty pharmaceutical company, today announced new retrospective health economic data on OFIRMEV® (acetaminophen) injection that shows managing post-orthopedic surgery pain with the addition of OFIRMEV to the treatment regimen was associated with shorter length of stay (LOS) and decreased hospitalization costs compared to opioid use alone. OFIRMEV is indicated for the management of mild to moderate pain, management of moderate to severe pain with adjunctive opioid analgesics and reduction of fever in patients 2 years of age and older.
The manuscript, recently published online in Advances in Therapy, is titled "Comparative Analysis of Length of Stay and Inpatient Costs for Orthopedic Surgery Patients Treated with IV Acetaminophen or Opioids for Postoperative Pain." Researchers at the University of Washington conducted the analysis, which was supported by a grant from Mallinckrodt.
This retrospective cohort analysis of the Premier Inc. (Premier) inpatient hospital database from Jan. 1, 2009 to June 30, 2015 compared orthopedic surgery patients who received perioperative pain management combining intravenous (IV) acetaminophen and IV opioids to those who received only IV opioids starting on day of surgery and continuing up to the second day following surgery. The analysis included 485,895 orthopedic surgery patients from U.S. hospitals, with 174,805 patients (36%) receiving IV acetaminophen. Surgeries included total knee and hip replacements or revisions, fracture surgery and other orthopedic procedures.
Key findings from this retrospective study were:
"Multimodal analgesia is a treatment approach endorsed by numerous medical societies and The Joint Commission, and it is included in the American Pain Society guidelines for post-surgical pain management," said Steve Romano, MD, Senior Vice President and Chief Scientific Officer of Mallinckrodt. "OFIRMEV, which is used in a variety of surgical and non-surgical settings, can be an important component of a multimodal approach to manage acute pain."
"We observed significant economic differences in length of stay and hospitalization costs among orthopedic surgery patients whose pain was managed with a combination of IV acetaminophen and opioids compared to IV opioids alone," said Principal Investigator Ryan Hansen, Pharm.D., Ph.D., Research Assistant Professor of Pharmacy and Health Services (adjunct) at the University of Washington. "Real-world data such as this can help guide decision-making among health care professionals."
IMPLICATIONS OF THE DATA
This analysis may offer important insight on possible ways to help provide savings to the hospital system in the orthopedic surgical setting. These findings support a similar retrospective study published in 2015 in the orthopedic patient population.1
The Advances in Therapy manuscript can be accessed here:
LIMITATIONS OF THE STUDY
ABOUT OFIRMEV (Acetaminophen) Injection
OFIRMEV (acetaminophen) injection is indicated for the management of mild to moderate pain, management of moderate to severe pain with adjunctive opioid analgesics, and reduction of fever. OFIRMEV (acetaminophen) injection is the first and only intravenous (IV) formulation of acetaminophen to be approved in the United States. The U.S. Food and Drug Administration approved OFIRMEV in November 2010. OFIRMEV is available to hospitals and outpatient and ambulatory surgical centers across the U.S.
IMPORTANT RISK INFORMATION
For additional Important Risk Information, including complete boxed warning, see Full Prescribing Information.
Mallinckrodt is a global business that develops, manufactures, markets and distributes specialty pharmaceutical and biopharmaceutical products and therapies, as well as nuclear imaging products. Areas of focus include autoimmune and rare diseases in specialty areas like neurology, rheumatology, nephrology, pulmonology and ophthalmology; immunotherapy and neonatal respiratory critical care therapies; analgesics and hemostasis products; and central nervous system drugs. The company's core strengths include the acquisition and management of highly regulated raw materials and specialized chemistry, formulation and manufacturing capabilities. The company's Specialty Brands segment includes branded medicines; its Specialty Generics segment includes specialty generic drugs, active pharmaceutical ingredients and external manufacturing; and the Nuclear Imaging segment includes nuclear imaging agents. To learn more about Mallinckrodt, visit www.mallinckrodt.com.
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1 Apfel C, et al. Effect of i.v. acetaminophen on total hip or knee replacement surgery: A case-matched evaluation of a national patient database. Am J Health-Syst Pharm. 2015; 72:1961-8.