There are a number of Investigator-Initiated Research (IIR) and External Collaborative Research (ECR) studies related to Mallinckrodt products in varying stages of completion. Click on the links provided below to learn more.
To access our online submission portal please click here: IIR/ECR Portal
ACTH as a Re-Emerging Therapy for Uveitis (The ACTHAR Study)
ACTH for Cutaneous Sarcoidosis Open Label Study
Acthar® Gel Stimulation of Neurosteroid Synthesis
Acthar in Rheumatoid Arthritis, Histologic and Functional Effect on Synovium
Acthar in the Treatment of Lupus Nephritis
A single-site, investigator-initiated, open-label trial of H.P. Acthar Gel in subjects with moderately to severely active ankylosing spondylitis (AS)
Biomarkers to Characterize Subtypes of Neuroinflammation in Infantile Spasms and Responsiveness to ACTH
BRIGHT-MS Study: Utility of ADC Maps in Patients with Acute Demyelinating Lesions
Clinical Impact of Acthar in the Psoriatic Arthritis Patient
Effect of ACTH in Interactions Between Antigen Presenting Cells and CD4 Tcells- Relapsing Remitting MS
Ocular Sarcoidosis: Open Label Trial of Acthar Gel
Open Label Proof of Concept Study to Evaluate Efficacy and Safety of ACTH Gel in Refractory DM/PM
Outcomes of Patients with Infantile Spasms Treated with ACTHAR Gel
Phase 4 Trial of Neuroprotection with ACTH in Acute Optic Neuritis
Use of ACTH in RA Related Flares
Use of Acthar in CKD Stage V or ESRD Patients in Preparation for a Kidney Transplant
Use of CXCL9 as a Biomarker of Acthar Efficacy
A Single-Center, Randomaised, Controlled Trail of the Efficacy and Safety of the Investigations drug “Inhaled Nitric Oxide (INOflo)” for the Patients with Severe Right Heart Failure Due to Pulmonary Hypertension
A Prospective, Multicenter Registry for Premature Newborns with Severe Pulmonary Hypertension
Effect of Nitric Oxide on Key Hox Transcription Factor Proteins During ELBW O2-Induced Lung Injury
The impact of fluctuating arterial oxygen saturation on cerebral autoregulation in preterm infants with late onset hypoxemic respiratory failure
Improvement in Acute Respiratory Parameters in Preterm Infants Under 34 Weeks Gestation after Initiation of INO in the Setting of Hypoxemic Respiratory Failure
Inhaled Nitric Oxide after Out-Of-Hospital Cardiac Arrest
Inhaled Nitric Oxide and Hypoxic Brain Injury in the Newborn
Inhaled NO In Hyperoxia-Mediated Decreased Alveolarization In RHAMM Knockout Mice
INO following Traumatic Brain Injury
Neuroprotective effects of inhaled nitric oxide in a newborn rat pup model of hypoxic-ischemic encephalopathy
Nitric Oxide (NO) - A potent anticoagulant for cardio pulmonary bypass (CPB) and Extracorporeal Membrane Oxygenator (ECMO) Therapy
Nitric Oxide Responsivity in Infants with Severe Chronic Lung Disease
Alternatives to heparin on ECMO
Treatment of delayed pulmonary transition in extremely preterm infants & bronchopulmonary dysplasia
Utilization of inhaled nitric oxide therapy in preterm infants in Canadian neonatal intensive care units
Differences in Outcomes Between Teaching and Non-teaching Hospitals in Patients with HRS
Hemodynamic profile of Terlipressin and Octreotide in patients with cirrhosis and portal hypertension (HVPG ≥ 12mmHg)
The impact of continuous Terlipressin infusion on sarcopenia and ascites in end-stage liver disease
The impact of continuous Terlipressin infusion on cirrhotic cardiomyopathy in end-stage liver disease
The Impact of Acute-on-Chronic Liver Failure on Survival in Patients with Decompensated Cirrhosis
Terlipressin bolus vs continuous infusion in patients with Variceal hemorrhage
Tumor-specific immunity after extracorporeal photopheresis in patients with Sézary syndrome at single-cell resolution
A multi- center randomized phase II study comparing corticosteroids alone versus corticosteroids and Extracorporeal Photophoresis (ECP) as first-line treatment of standard risk Grade II acute graft-versus-host disease after allogenic stem cell transplantation
ECP in high-risk chronic graft-versus-host disease
Large Single Center Retrospective Analysis of Efficacy of Extracorporeal Photopheresis in Treatment of Chronic Graft versus Host Disease
Multicenter analysis of efficacy and outcomes of extracorporeal photopheresis as treatment of chronic lung allograft dysfunction
Observational for ECP in acute or chronic GvHD after allogeneic hematopoietic stem cell transplantation for hematological malignancies
Prophylactic Use of Extracorporeal Photopheresis (ECP) after Lung Transplantation
The Siena ECP Registry and Software - Research protocol for extracorporeal photopheresis in lung transplant patients
Interactions between Macrophages and Engineered Tissues
Pre-Clinical Assessment of StrataGraft™ for Deep Partial and Full Thickness Burns in Normal and SCID Pigs
Scarring in Stratagraft-treated vs. autograft-treated burn wounds: a clinical and histological investigation
Impact of photopheresis in the prevention of acute rejection in highly sensitized de novo kidney transplant recipients
Improved outcome of chimeric antigen receptor (CAR) T cell therapy supported by extracorporeal photopheresis treatment - the effect of methoxypsoralen and UV-A light versus steroids on CAR T cell function
Phase 1/2 Trial to determine the safety and efficacy of Extracorporeal photopheresis as treatment for steroid-refractory immune related adverse events after immune checkpoint inhibitor therapy
Retrospective data analysis of patients with systemic sclerosis and extracorporal photopheresis versus standard of care therapy